A review of case reports and clinical studies published between 2009 and 2019 concluded that estrogen is “an important precipitating and aggravating factor that triggers HAE-C1-INH attacks.” [12] Hormonal fluctuations during puberty, menses, pregnancy, perimenopause, and menopause all affect the disease course and frequency of symptoms [7]. The gene discussed is SERPING1; the disease is hereditary angioedema.