HFFs treatment also could down-regulate the LN and PCIII of liver tissues, the indicators of liver fibrosis evaluated by ELISA (Fig. 9D) and significantly decreased α-SMA, collagen I, TGF-β, TIMP1, and MMP9 expressions evaluated by Q-PCR, similar to UC-MSCs treatment (Fig. 9E). This evidence concerns the gene TIMP1 and Hepatic fibrosis.