ApoE4 exhibits lower autophagic flux compared to ApoE3, the apoE4-Aβ complex is less stable than ApoE3-Aβ, and ApoE4 has a lower facilitation effect on Aβ clearance than apoE3 [115, 116], which may be one of the factors that promote the progression of AD. The gene discussed is APOE; the disease is Alzheimer disease.