CYP3A4 and neoplasm: On this basis, simple structural optimization was carried out to obtain AMG232 [54], which had better PK parameters in rhesus monkeys, low inhibitory activities against CYP, CYP3A4 and PXR, low internal clearance rates in human hepatocytes and rats, and 2500 times higher selectivity for tumor cells with high expression of wild-type p53 than that for p53 knockout tumor cells.