Nutlin-3a can compete for binding sites in the N-terminus of MDM2 protein and p53 (Phe19, Trp23, Leu26) to block the binding between MDM2 and p53 and reduce the degradation of p53, which then results in induction of apoptosis of tumor cells, reversal of the immunosuppressive microenvironment and triggering of immunogenic cell death [21]. Here, MDM2 is linked to neoplasm.