It has been reported that heterozygous pathogenic variants in TP63 are associated with a total of seven diseases: ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3; OMIM #604292); split-hand/foot malformation 4 (SHFM4; OMIM #605289); ankyloblepharon-ectodermal defects-clefting syndrome (AEC; OMIM #106260); acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome; OMIM #103285); limb-mammary syndrome (LMS; OMIM #603543); Rapp-Hodgkin syndrome (RHS; OMIM #129400); and orofacial cleft 8 (OFC8; OMIM #618149) [11]. This evidence concerns the gene TP63 and split hand-foot malformation 4.