In soft tissue sarcomas, high expression of VISTA may predict the favorable prognosis of patients (P = 0.043), which can be attributed to the increased TIL, especially for CD3+ cells, however, more frequent VISTA is found in higher FNCLCC grade (G3 vs. G2, P = 0.019), exactly opposite of what is predicted without further explanation [25]. The gene discussed is VSIR; the disease is soft tissue sarcoma.