VSIR and colorectal cancer: However, Wu et al. consider that the high expression of VISTA predicts the better prognosis of colorectal cancer patients (P = 0.005), with high lymphocyte infiltration and low tumor stage, high AJCC III-IV stages tumors have lower VISTA expression, the order of VISTA expression is as follows: pT1 > pT2 > pT3 > pT4 [107].