VSIR and familial pancreatic carcinoma: In pancreatic cancer, high expression of VISTA is found in tumor cells, positively associated with the infiltration of CD19+ B cells, CD3+ T cells and CD68+ macrophages, besides, frequent VISTA expression is a risk factor of tumor grade (HR = 3.911, P = 0.012), T stage (HR = 2.885, P = 0.006), N stage HR = 4.221, P = 0.001) and M stage (HR = 5.57, P = 0.001) but a protective factor for patients survival ( HR = 0.588, P = 0.029) [77].