VSIR and metastatic malignant neoplasm in the lymph nodes: In NK/T cell lymphoma, high expression of VISTA is correlated with more infiltration of Foxp3+ Tregs, both expressions of VISTA (P = 0.001, HR = 2.05, 95% CI: 1.29–3.25) and PD-L1 (P = 0.005, HR = 1.93, 95% CI: 1.22–3.07), respectively, are risk factors and predict poor PFS (progression free survival) and OS (overall survival), the upregulation of VISTA and PD-L1 inhibit the activation and proliferation of CD8+T cells, which are associated with lymph node metastasis (P = 0.004) and the advanced stage (P = 0.002) [80].