indicating that IGSF11 may serve as a ligand and receptor simultaneously, to interact with PD-1 and VISTA to create an inhibitory immune microenvironment, which is related to the poor prognosis [71], however, this study only proved the role of IGSF11 in advanced glioma, but the prognostic role of IGSF11 in other tumors has not been demonstrated, and there is a great space for scientific research and exploration. The gene discussed is IGSF11; the disease is central nervous system cancer.