In colorectal cancer, hypoxia can induce HIF1α (hypoxia-inducible factor 1-alpha), binding to the promoter of VISTA to increase the expression on MDSCs, enhance the inhibition of MDSCs to T cell function, which can be the reason for high VISTA expression indicating the poor prognosis of colorectal patients, however, the survival analysis is on the foundation of GSE40967, the survival association is confirmed only at the mRNA level but not in protein level [105]. Here, HIF1A is linked to colorectal cancer.