Similar results are proven in colorectal cancer, the high expression of C10orf54 (encoding VISTA) is positively associated with other immune checkpoints like PD1/PD-L1, TIGIT, BTLA and HAVGR2, and positively related with the anti-inflammation factors like Foxp3 and TGFb1, but negatively associated with the Kras mutation, also meaning that VISTA may be involved in immune escape, thus further investigations are warranted [44]. This evidence concerns the gene VSIR and colorectal cancer.