Moreover, high expression of VISTA is associated with advanced tumor stage (67.7% vs. 32.3%, pT1 vs. pTa and pTis, R = 0.325, P < 0.001), high pathologic grade (71.0% vs. 29.0%, pT1 vs. pTa and pTis, R = 0.438, P < 0.001) and tumor size larger than 3 cm (R = 0.322, P < 0.001) [98]. The gene discussed is VSIR; the disease is neoplasm.