IGSF11 and hepatocellular carcinoma: Compared to the minimal expression of IGSF11 in the normal tissue, IGSF11 is highly expressed in gastrointestinal tumors, including colorectal cancer, hepatocellular carcinoma and gastric cancer [32], however, the role of IGSF11 in esophageal carcinoma (which is also a part of digestive tract), is still unknown.