In TNBC (triple-negative breast cancer), Cao et al. indicate that higher expression of VISTA is less associated with lymph node metastasis but more related to the infiltration of TILs, especially for CD4+ TILs, more VISTA+ immune cells are found in stage I/ II patients and basal-like subtype with favorable OS, especially for T1-2N0 stage patients [99]. Here, CD4 is linked to metastatic malignant neoplasm in the lymph nodes.