VSIR and central nervous system cancer: At present, the relationship between IGSF11 and tumor prognosis prediction is only reflected in glioma, which may coordinate with PD-1, especially in advanced human gliomas, the high expression of IGSF11 is associated with poor overall survival (P = 0.0004) the high co-expression of PD-1 and VISTA in advanced human gliomas show poorer survival (P < 0.0001, P = 0.0078), the protein level of IGSF11 is not related to tumor grades and histologic type, but IGSF11 is found expressed in tumor samples of all grades, on both glioma cells and tumor-associated inflammatory cells.