In the present study, we aimed to identify the genotype of NFKB1 gene rs28362491 mutation in high-risk patients who visited our hospital for chest pain and tightness and were diagnosed with developed coronary artery stenosis but not yet coronary artery disease using coronary angiography, and also to follow up the patients for MACCEs to explore the association between the NFKB1 gene mutations and the occurrence of MACCEs, and clarify whether NFKB1 genotyping is beneficial for identifying the occurrence of MACCEs and improving the prognosis of patients with cardiovascular diseases. Here, NFKB1 is linked to coronary stenosis.