NFKB1 and cardiovascular disorder: Conclusively, in the present study, we confirmed that DD genotype of NFKB1 gene is an independent risk factor associated with MACCEs, and detection of rs28362491 polymorphism in NFKB1 gene is beneficial for identifying patients who are at high risk of cardiovascular diseases, for whom the occurrence of MACCEs may be reduced through effective interventions.