Subsequently, study of genome-wide association analysis on the lipid level in 8,344 subjects found that the genes LPL, TRIB1, APOA1-C3-A4-A5, LIPC, CETP, and LDLR were correlated with the lipid level changes, and that the individual genetic variation and cumulative effects were independent risk factors associated with the increase in lipid levels and hyperlipidemia [23]. The gene discussed is LDLR; the disease is hyperlipidemia.