Checkmate057 [4] and KEYNOTE-010 [6], these two clinical trial subgroup analysis results showed the comparison of ICIs compared with chemotherapy for advanced NSCLC in the EGFR mutation group, there was no significant difference in OS, and EGFR mutation patients did not benefit from immunotherapy and were not sensitive to immunotherapy. This evidence concerns the gene EGFR and non-small cell lung carcinoma.