PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Nor, to our knowledge, are any data available assessing whether this association is at least partially mediated by coexistence of the rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene or other genetic polymorphisms that confer greater susceptibility to NAFLD and NASH [19, 20].