In a meta-analysis of 27 observational studies that reported data on 2243 individuals (1545 patients with NAFLD and 698 controls), Polyzos et al. reported that control subjects had significantly higher plasma adiponectin levels compared to patients with simple steatosis alone (random-effects weighted mean difference [WMD] 3.0, 95% CI 1.57–4.43, I2 = 80.4%) or those with NASH (random-effects WMD 4.70, 95% CI 3.71–5.78, I2 = 84.1%) [17]. This evidence concerns the gene ADIPOQ and steatosis.