Similarly, several HOX genes including HOXD11 and HOXD12 which are known to be ATRA responsive in neuroblastoma cells, and to be able to induce growth arrest and differentiation in these cells [65], were significantly induced in WT but to a lesser degree or were not induced in BKO98 cells (Table S3, Fig. 6B). Here, HOXD12 is linked to neuroblastoma.