Moreover, our current study showed that several RNA splicing factors, including heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPCC), HNRNPU, HNRNPU-like protein 2, matrin-3 (MATR3), serine/arginine-rich splicing factor 6 (SRSF6), and RNA-binding protein Raly (RALY)39 were upregulated in patients with B-ALL. This evidence concerns the gene MATR3 and precursor B-cell acute lymphoblastic leukemia.