Second, tumours with extensive clonal substructure (i.e. ≥ 3 sub-populations; n = 4); these were completely aligned with the very high-risk (VHR) tumours assessed (i.e. both MYC-amplified MBGroup3 and both TP53-mutated/MYCN-amplified MBSHH). The gene discussed is MYCN; the disease is neoplasm.