Our work provided experimental evidence of peripheral leukocyte invasion into the brain during systemic inflammation after peripheral trauma using a transgenic zebrafish model and demonstrated the complex impacts of invading leukocytes on the CNS through il1b-regulated mechanisms, which provided a basis to stimulate the understanding of neurological disorders that occur after peripheral trauma and the development of novel therapeutic strategies by targeting leukocyte invasion. The gene discussed is IL1B; the disease is nervous system disorder.