Studies on the pathogenesis of articular cartilage disorders have identified the molecules involved, such as Interleukin 1 beta (IL-1ß), tumor necrosis factor alpha (TNF-α), Interleukin 6 (IL-6), Interleukin-8 (IL-8), and Matrix metalloproteinases (MMPs), and many studies on therapeutic interventions are underway and expected to be successful, which may revolutionize treatment soon3,4. This evidence concerns the gene IL1B and cartilage disease.