CES1 and Hyperglycemia: Here, we found that transgenic overexpression of miR-30d in β-cells systemically affected β-cell function in an expression-dependent manner: low-level of miR-30d (TgL) had mild effects on signaling pathways and displayed no significant phenotypic changes, whereas high-level of expression (TgH) impaired important signaling pathways and led to diet-induced hyperglycemia and β-cell dysfunction.