ATIC and rheumatoid arthritis: When the inheritance models were applied to the ancestry-specific stratification, it could be inferred that: (i) ATIC C347G (rs2372536) was associated with AR in Malay RA patients under dominant and additive models; (ii) the minor allele of ATIC T675C (rs4673993) under three genetic models (dominant, recessive and additive) may predict a higher success rate in MTX treatment among Malay RA patients (Table 5).