More importantly, when we overexpressed DYNC1I2 using CRISPR-Cas9-based activation in HHIP-AS1-transiently depleted cells, both proliferation and viability were restored (Fig. 3g and h), indicating that HHIP-AS1 exerts its pro-proliferative effects by controlling DYNC1I2 abundance in tumor cells. The gene discussed is DYNC1I2; the disease is neoplasm.