HHIP-AS1 is actively transcribed from a SHH-responsive bidirectional promoter shared with the SHH signaling intermediate HHIP. HHIP-AS1 knockdown leads to reduced tumor growth in SHH-driven tumors in vitro and in vivo by decreasing cell proliferation and inducing mitotic spindle deregulation. The gene discussed is HHIP; the disease is neoplasm.