Notably, HLA-II expression in tumor cells was not uniform across the genes examined, with significantly higher HLA-DRB1 than HLA-DQA1, HLA-DQB1, and HLA-DPB1 (p < 0.0001, Kruskal–Wallis) (Fig. 4c). The gene discussed is HLA-DPB1; the disease is neoplasm.