IGHG3 and neoplasm: And consistent with our scRNA findings, IgG1, and IgG3 positive cells showed an increasing trend in MPR tumor lesions (mean IgG1: 2.13% versus 1.41% versus 2.92%; mean IgG3: 0.32% versus 0.25% versus 0.52%), while IgA positive cells showed a decreasing trend in MPR tumor lesions (mean 1.62% versus 1.51% versus 0.72%; Fig. 2D, F).