TNFRSF4 and neoplasm: To validate their association with therapeutic response, we made a comparison of TNFRSF4 expression among C11-Tregs-FoxP3 of different tissue types of neoadjuvant non-MPR and MPR patients, and demonstrated that the expression of TNFRSF4 was significantly lower in P1, nearest non-tumor tissue (N), tumor tissue (T) and LNs in MPR than non-MPR patients, which was strikingly lower in MPR tumor tissues compared with non-MPR tumor lesions (Fig. 5E).