Consistently, it has been reported that Treg cells with the expression of TNFRSF4 were more immunosuppressive and facilitated tumor immune evasion, and promote tumor development in nasopharyngeal carcinoma, cutaneous squamous cell carcinoma and chronic myeloid leukemia [53–55]. This evidence concerns the gene TNFRSF4 and chronic myelogenous leukemia, BCR-ABL1 positive.