(1) SKP2 protein is highly expressed in ccRCC tumor tissues and cells; (2) overexpression of SKP2 enhances cell proliferation and clone-forming ability of ccRCC, while SKP2 depletion exhibits the opposite effect; (3) high levels of SKP2 predicts a worse patient survival, whose results are consistent with previous studies [15, 16]. This evidence concerns the gene SKP2 and neoplasm.