AKT1 and colorectal carcinoma: In order to investigate the role of lomitapide in cellular mTOR signaling events, CRC cells were treated with lomitapide for 4 h, after which reduced phosphorylation was observed at T389 of S6K1, S240/244 of S6, and T37/46 of 4E-BP1, but not at S473 of Akt nor at T202/Y204 of Erk (Fig. 2c).