It is still unclear if low insulin clearance and/or the resultant hyperinsulinemia is a compensatory response to low insulin sensitivity or is the driver of T2D in the black African women.51 Nonetheless, this is the first study to show that MVPA is associated with higher insulin clearance, independent of the effects of adiposity, and that this association is specific to women and not observed in men. The gene discussed is INS; the disease is type 2 diabetes mellitus.