Of note, we also showed that the L124P substitution in GLI1, identified in a basal cell carcinoma that had acquired resistance to vismodegib, dramatically weakened binding to SUFU and potentiated GLI1-driven transcription, suggesting that this mutation may account for the drug resistance seen in the patient (Figs 8 and 10). This evidence concerns the gene GLI1 and basal cell carcinoma.