KLK3 and obesity due to melanocortin 4 receptor deficiency: Many risk factors have been linked to PC, of which age, genetic factors, and ethnicity are the most suggested.3 In addition, several other factors, including diet, obesity, infections, and inflammation were also evoked.4 Abnormal digital rectal examination (DRE) and elevated plasmatic levels of prostate-specific antigen (PSA) are the most common findings that initiate further investigation for malignancy in the prostate gland.