SHOC2 and RASopathy: Rasopathy-associated mutations SHOC2(M173I) and Q269_H270delinsHY (Q269H/H270Y); MRAS G23V, T68I and Q71R; PP1Cα P50R (corresponding to PP1Cβ P49R); and non-rasopathy SHOC2 LOF mutations D175N and E457K all map to interaction sites.