SHOC2 and RASopathy: A complex comprising the M173I rasopathy mutant of the SHOC2 LRR domain (80–582), GTPase-deficient MRAS(Q71R) and WT PP1Cα was isolated and crystalized, diffracting to 1.95 Å (Rcryst = 0.1838; Rfree = 0.2209; Fig. 1d, Methods and Extended Data Table 1).