Interestingly, when taxa were clustering according to the diet, the obese NASH-associated taxa were positively correlated with (i) greater viral RNA loads in the lung and the liver and (ii) pro-inflammatory marker profiles in the lung (the histology score and mRNA levels of inflammation-associated factors), the colon (mRNA levels of Ifng and S100a9) and the liver (mRNA levels of pro-fibrotic factors such as Col1a1, mmp2, Ecm1 and Lcn2). The gene discussed is ECM1; the disease is metabolic dysfunction-associated steatohepatitis.