It is an inflammatory organic state, characterized by insulin resistance and, consequently, it presents a complex triad, namely: atherosclerosis; pro-inflammatory cell catharsis [emphasis on Interleukin-1 (IL-1), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Ultrasensitive C-Reactive Protein (us-CRP)] and the MS components themselves.5 The gene discussed is TNF; the disease is atherosclerosis.