TLR4 and periodontitis: Our previous study showed that fenofibrate reduced pro-inflammatory cytokines in LPS-induced acute uveitis by downregulating TLR4 in the RPE and iris.24 LPS from P. gingivalis is is a key factor to develop periodontitis and LPS is the agonist of TLR4, however, it is unclear if fenofibrate reduces the production of pro-inflammatory cytokine in the periodontitis related to downregulating the TLR4, which requires further studies.