Although the exact mechanism is unknown, it has been hypothesized that the causative role of P.g in the periodontitis may be by synthesizing pathogenic factors by its virulence factors.7 Lipopolysaccharide (LPS), a key component in the outer membrane of P.g , is a causative virulence factor of P.g. LPS plays a major pathogenic role that initiate and enhance the inflammation in the periodontitis.8 LPS can function as a pathogen-associated molecular pattern to trigger or mediate the inflammatory response by binding to the Toll-like receptor and CD14. Here, CD14 is linked to periodontitis.