There are several studies of PPARs in the periodontitis, for example, Taskan’s study reported that the PPARγ level increased in patients with periodontitis,25 whereas Briguglio’s study of WY-14643, a potent PPARα agonist, in an experimental rat model showed that the inflammatory process associated with experimental periodontitis improved.26 We assessed the pathogenic role of PPARα and the effects of PPARαactivation/defect on inflammation and bone loss in periodontitis. This evidence concerns the gene PPARA and periodontitis.