This study revealed that Cr (III) up-regulates FOXP3 expression which means subsequent remission of RA (Kanjana et al. 2020) and this goes in line with the up-regulation of the anti-inflammatory cytokine IL 10 (Greenhill et al. 2014) in Cr (III) treated RA group that was even exceeding that of prednisolone in this study. Here, FOXP3 is linked to rheumatoid arthritis.