To date, 19 genes are implicated in MSMD (CYBB, IFNGR1, IFNGR2, IFNG, IL12RB1, IL12B, IL23R, IL12RB2, ISG15, IRF8, JAK1, NEMO, RORC, SPPL2A, STAT1, TBX21, TYK2, USP18, ZNFX1). This evidence concerns the gene IL23R and Mendelian susceptibility to mycobacterial diseases.