HMGB1 and metastatic malignant neoplasm in the lymph nodes: Univariate analysis revealed that pM stage, lymph node metastasis, venous invasion, HMGB1 expression, and co-expression of HMGB1 and RAGE were significantly associated with poor survival rates (P ≤ 0.05, P ≤ 0.001) (Table 6).