Compared to virus-specific Th1 cells, this tumor-specific CD4+ T cell state differentially expressed genes associated with Th2 cells, including Igfbp7, Ccl1, Ccr8, and Il13, and downregulated Th1-associated genes, including Ccl5 and Ly6c2 (Figure 7E–F). Here, CCR8 is linked to neoplasm.