In particular, the decreasing cancer incidence in Klf1K74R/K74R mice, also seen in the FMD treatment, is most likely due to KLF1(K74R) influencing reprogramming of the immune‐modulatory cascades of hematopoietic/blood system and improvement in CD8+ T‐cells and NKT cell infiltration (Figures 4 and 5 and Figure S4, Supporting Information). Here, CD8A is linked to cancer.