Likewise, the extent of glomerular sclerosis, dilatation of Bowman's capsule and shrinkage of glomeruli in the renal corpuscles of Klf1K74R/K74R mice was also significantly lower than that in Klf1+/+ mice (9.24 ± 7.60% vs 24.53 ± 9.77%, p < 0.05) (Figure 3G). The gene discussed is KLF1; the disease is Glomerular sclerosis.