Moreover, comparison of CyTOF analysis of splenocyte composition and immunohistochemical (IHC) analysis of tumor infiltrating CD8+ T cells and NKT cells of engrafted B16F10 melanoma tumor in lung sections from Klf1+/+ mice and Klf1K74R/K74R mice revealed that the higher tumor infiltration of CD8+ T cells and NKT cells were significantly exhibited in Klf1K74R/K74R mice as compared to matched tumor tissue in Klf1+/+ mice (Figure 5E,F and Figure S5D, Supporting Information). Here, KLF1 is linked to melanoma.