KLF1 and Hepatic fibrosis: Consistent with the results in cardiac and liver tissues, evaluation of histopathological findings in aged animals showed that the development of hepatic fibrosis in Klf1K74R/K74R mice was significantly reduced to 47% compared with Klf1+/+ mice at age over 24 months (14.84 ± 8.57% vs 31.16 ± 10.40%, p < 0.05) (Figure 3E).