The concept of paracrine restraint of α‐cell secretion by insulin (Unger & Orci, 2010) (and other β‐cell factors [Rorsman et al., 1989]) is supported by experiments where isolated α‐cells respond inappropriately to hyperglycemia by secreting glucagon (Ishihara et al., 2003). Here, GCG is linked to Hyperglycemia.