Surprisingly, contrary to findings from a mouse model of acute liver failure‐induced hepatic encephalopathy (McMillin et al., 2016, 2017), the present study showed no differences in the cerebellar expression of genes related to bile acid signaling such as farnesoid X receptor (FXR), small heterodimer partner and S1PR2 between BDL and SHAM groups. Here, S1PR2 is linked to acute liver failure.