Taken together with prior studies, these observations suggest a model (Figure 8) whereby many of the metabolic effects of mTORC1 inhibition are likely mediated through activation of C/EBP-β, and that both mTOR and C/EBP-β are druggable targets to induce positive effects in the context of diet-induced obesity. This evidence concerns the gene MTOR and obesity due to melanocortin 4 receptor deficiency.