Low frequency of B cells can likely be a consequence of low density of fat-associated lymphoid clusters in omental and subcutaneous human adipose tissues, which are structures associated with B cell accumulation Notably, B cell depletion improved insulin and glucose responses in obesity/T2D, which correlated with decreased inflammation (DeFuria et al., 2013). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.