They found that mutations in epigenetic modifiers including TET2 and ASXL1, and RNA splicing factors including SF3B1 and SRSF2, are the predominant founder events in MDS, while genes involved in signaling cascades including JAK2 and CBL, transcription factors including RUNX1 and ETV6, and cytogenetic lesions including monosomy 7, trisomy 8, and del (5q), were almost exclusively acquired as late events (Mossner et al., 2016). Here, RUNX1 is linked to myelodysplastic syndrome.