Multiple groups have shown that many of the hematologic features of MDS can be partial recapitulated in single-gene genetic mouse models, such as SRSF2, U2AF, SF3B1, and ASXL1 knock-in or knock-out mouse models (Abdel-Wahab et al., 2013; Kim et al., 2015; Shirai et al., 2015; Mupo et al., 2017). This evidence concerns the gene ASXL1 and myelodysplastic syndrome.