The innate immune cytokine IL-8 and its receptor CXCR2 were found to be concomitantly overexpressed in high-risk MDS-SCs and AML LSCs when compared with healthy counterparts, suggesting that an IL-8/CXCR2 autocrine loop promotes MDS-SC and AML LSC function (Schinke et al., 2015). Here, CXCR2 is linked to acute myeloid leukemia.