Parkin KO or overexpression (OE) did not result in cardiac dysfunction over 20 weeks. TEM at 6 weeks after Parkin KO look normal, Myh6-Parkin transgenic mice at 30 weeks did not show abnormalities in mito content, mito area and aspect ratio. TEM showed that Drp1 KO exhibit loss of mitochondria 6 weeks after Drp1 deletion, Parkin/Drp1 DKO delays cardiomyopathy of the Drp1 KO, and partially restore mitochondrial content. This evidence concerns the gene PRKN and cardiomyopathy.