Dilated cardiomyopathy (DCM) and heart failure (HF) 6–8 weeks after KO. Mitochondria have preserved cristae; however, they were larger and more elongated. In this study, mitochondrial autophagy and mitochondrial stress were assessed using p62, LC3, LONP2, AFG3L2, and Hsp60 Western blots. The gene discussed is AFG3L2; the disease is dilated cardiomyopathy.