Dilated cardiomyopathy (DCM) and heart failure (HF) 6–8 weeks after KO. Mitochondria have preserved cristae; however, they were larger and more elongated. In this study, mitochondrial autophagy and mitochondrial stress were assessed using p62, LC3, LONP2, AFG3L2, and Hsp60 Western blots. This evidence concerns the gene AFG3L2 and heart failure.