MAPT and Alzheimer disease: The abnormal deposition of senile plaques containing ß-amyloid (Aβ) and neurofibrillary tangles (NFT) composed of hyperphosphorylated tau are major pathognomonic neuropathologies of AD, and are thought to play a key role in its development (Hardy and Allsop, 1991; Thal et al., 2002; Perl, 2010).