Moreover, in peripheral blood mononuclear cells from patients with preeclampsia, progesterone also suppresses the TLR4 and its downstream signaling in a dose-dependent manner (Zhu et al., 2013), showing that the cardioprotective effects of estrogens under injury may be, at least in part, associated with a downregulation of TLRs. The gene discussed is TLR4; the disease is preeclampsia.