Most of the patients with severe COVID-19 have significantly increased levels of pro-inflammatory cytokines and chemokines in the serum, including IL-6, IL-2, IL-1β, IL-8, IL-17, granulocyte (G)-colony-stimulating factor (CSF), granulocyte-macrophage (GM)-CSF, C–X–C motif chemokine ligand (CXCL)10, C–C motif chemokine ligand (CCL)2, CCL3, and TNF (Xu et al., 2020; Qin et al., 2020). The gene discussed is TNF; the disease is COVID-19.