TP53 and cancer: Elephants appear to have an enhanced apoptotic response to DNA damage owing to their extensive number of TP53 (EP53) retrogenes (Abegglen et al., 2015; Sulak et al., 2016) and, as a result, develop cancer at lower rates than expected for their body size and lifespan (Abegglen et al., 2015; Tollis et al., 2020).