MUP proteins are related to members of the lipocalin family, which have documented connections to a variety of fibrotic conditions (Eichler et al., 1999; Ikezoe et al., 2014; Chen et al., 2020), as well as obesity and insulin resistance (Wang et al., 2007; Yan et al., 2007). The gene discussed is MUPP; the disease is obesity due to melanocortin 4 receptor deficiency.