Given that TLRs (Kim et al., 2012), Ciita (Deng et al., 2013) and Nrpl3 (Stienstra et al., 2010) are known to be induced in obese adipose tissue or to support adipocyte inflammation, it can be justifiably speculated that their transcriptional induction in adipocytes makes an important contribution to PU.1’s action in promoting inflammation and insulin resistance. Here, SPI1 is linked to Insulin resistance.