It has been suggested that the coordination of antigen-specific adaptive immune responses by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific CD4+ T cells and CD8+ T cells limits the severity of COVID-19 but that this coordination is disrupted in elderly individuals (≥65 years of age) (Rydyznski Moderbacher et al., 2020). The gene discussed is CD4; the disease is COVID-19.