Because CMV infection markedly affects CD8+ T cell homeostasis and the generation of senescent T cells (Nikolich-Zugich, 2008; Wertheimer et al., 2014; Klenerman and Oxenius, 2016), we re-analyzed the AIM+ cell phenotypes from young individuals as CMV+ (n = 14) and CMV− (n = 16). Here, CD8A is linked to cytomegalovirus infection.