When evaluating the experimental periodontitis induced by ligature, some studies detected increased levels of serum α amyloid (SAA), IL-6, vascular endothelial growth factor (VEGF), receptor of activator NF-κB ligand (RANKL), CCL5, CXCL10, and B-cell activating factor (BAFF) at the serum level (Arimatsu et al., 2014; Matsuda et al., 2015; Komazaki et al., 2017; Jia et al., 2018; Palioto et al., 2019; Hamamoto et al., 2020). Here, VEGFA is linked to periodontitis.