A second recently published cohort also showed severe GSH depletion in older subjects (Ratio of GSH-F:GSSG of 1.1 in older subjects compared to 10.1 in young subjects, p-value = 0.0003, n = 8 each group) that were accompanied by high levels of insulin resistance (HOMA-IR of 11.4 in older adults compared to 1.7 in young subjects, p-value<0.0001) and chronic systemic inflammation (CRP: young adults = 2.4 mg/L; older adults = 4.8 mg/L, p-value < 0.0001) (Kumar et al., 2021a). The gene discussed is CRP; the disease is Insulin resistance.