C. elegans AD, PD, HD and ALS models have been used to show that proteostasis collapse are associated to a failure in amyloid, tau, α-synuclein, and extended polyQ clearance (Voisine et al., 2010; Lehrbach and Ruvkun, 2019; Ruz et al., 2020) (see below). The gene discussed is SNCA; the disease is Alzheimer disease.