IL1B and neoplasm: Although Foxp3+ ROR-γt+ cells were also shown to be present in tumors and contribute to tumor immune evasion and autoimmunity control (Downs-Canner et al., 2017; Kim et al., 2017; Bhaskaran et al., 2021a), the role of increased IL-1β in the context of aging and carcinogenesis remains to be investigated.