Interestingly, in this same study, the STIM2 splice variant STIM2.1, shown previously to have an inhibitory effect on SOCE in T-cells (Miederer et al., 2015), was shown to be significantly reduced in LV of HF patients with a reduction in the ratio of STIM2.1/STIM2. The gene discussed is STIM2; the disease is hydrops fetalis.