ORAI1 and cardiac hypertrophy: However, upon the discovery of STIM1 and Orai1 as key regulators of SOCE and with STIM1/Orai1-mediated SOCE being associated with cardiac hypertrophy (Ohba et al., 2009; Voelkers et al., 2010; Hulot et al., 2011; Luo et al., 2012), there was a growing appreciation of this signaling mechanism in the heart.