ORAI1 and acute pancreatitis: To determine the role of Orai1 in pancreatic acinar cell injury and acute pancreatitis, Wen et al. transfected Orai1 into human and mouse acinar cells and found that the application of Orai1 inhibitors prevented acinar cell necrosis (Wen et al., 2015), suggesting a role of Orai1-mediated Ca2+ overload in acute pancreatic cell necrosis.