A recent study examining the expression of STIM and Orai isoforms in human failure samples indicated that in addition to the expression of STIM1 and Orai1 being increased and decreased in the left ventricles of heart failure patients, respectively, the expression of STIM2, Orai2, and Orai3 remained unchanged (Cendula et al., 2019). Here, STIM1 is linked to heart failure.