After the establishment of its role in cardiac hypertrophy, there was significant controversy in the field as to the relevance of STIM1/Orai1-mediated SOCE in the non-diseased heart due to the predominant regulation of cardiac Ca2+ handling on a beat-by-beat basis by voltage-gated Ca2+ handling; therefore, the field began to focus their attention on determining the physiological role of both STIM1 and Orai1 in the heart. The gene discussed is ORAI1; the disease is cardiac hypertrophy.